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MICU1 單克隆抗體

貨號(hào) 品牌 CAS 規(guī)格 銷(xiāo)售價(jià)(RMB) 折扣價(jià)(RMB) 備注 數(shù)量
ABM0061-100μL Abbkine 無(wú) 100μL 1998 1998 無(wú)
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商品信息

產(chǎn)品英文名稱(chēng)MICU1 Monoclonal Antibody
免疫原重組蛋白
宿主小鼠
反應(yīng)性人, 大鼠, 小鼠
應(yīng)用IF, IHC-P, WB
實(shí)驗(yàn)建議最佳的工作稀釋比例需要客戶(hù)摸索優(yōu)化。建議的起始嘗試的稀釋比為：WB：1:1000-1:2000，IF：1:100-1:200，IHC-P：1:100-1:200。
克隆性單克隆
純化工藝使用表位特異性的免疫原，通過(guò)親和層析，從小鼠腹水中親和純化抗體。

商品屬性

產(chǎn)品形式液體溶液
濃度1 mg/ml
分子量55 KD
儲(chǔ)存緩沖液PBS緩沖液（pH 7.4），含有0.02％疊氮化鈉（防腐劑）和50％甘油。
保存建議自發(fā)貨之日起，-20°C可穩(wěn)定保存1年。為最大限度的避免損失，請(qǐng)?jiān)诖蜷_(kāi)管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復(fù)凍融。
運(yùn)輸條件藍(lán)冰運(yùn)輸
警告本文列出的產(chǎn)品僅供研究使用，不適用于人類(lèi)或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何專(zhuān)利或許可證。對(duì)于使用本產(chǎn)品可能發(fā)生的專(zhuān)利侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。

附加信息

背景Most PKMT substrates are histone proteins and transcription factors, emphasizing the importance of lysine methylation in regulating chromatin structure and gene expression. Lys9 of histone H3 is mono- or di-methylated by G9A/GLP and tri-methylated by SETDB1 to activate transcription. JHDM3A-mediated demethylation of the same residue creates mono-methyl Lys9 and inhibits gene transcription . Tumor suppressor p53 is regulated by methylation of at least four sites. p53-mediated transcription is repressed following mono-methylation of p53 at Lys370 by SMYD2; di-methylation at the same residue further inhibits p53 by preventing association with 53BP1. Concomitant di-methylation at Lys382 inhibits p53 ubiquitination following DNA damage. Mono-methylation at Lys382 by SET8 suppresses p53 transcriptional activity, while SET7/9 mono-methylation at Lys372 inhibits SMYD2 methylation at Lys370 and stabilizes the p53 protein. Di-methylation at Lys373 by G9A/GLP inhibits p53-mediated apoptosis and correlates with tri-methylation of histone H3 Lys9 at the p21 promoter . Overexpression of PKMTs is associated with multiple forms of human cancer, which has generated tremendous interest in targeting protein lysine methyltransferases in drug discovery research.
基因ID10367
其它該抗體可檢測(cè)內(nèi)源蛋白
蛋白質(zhì)IDQ9BPX6